The Colorado Department of Agriculture’s State Veterinarian’s Office has placed 69 locations under quarantine after horses and one cow tested positive for Vesicular Stomatitis (VS). The quarantines are located in Adams, Boulder, Douglas, El Paso, Larimer, and Weld counties; results on additional tests in those and other counties are pending. VS can be painful for animals and costly to their owners. The virus typically causes oral blisters and sores that can be painful causing difficulty in eating and drinking. Veterinarians and livestock owners who suspect an animal may have VS or any other vesicular disease should immediately contact State or federal animal health authorities. Livestock with clinical signs of VS are isolated until they are healed and determined to be of no further threat for disease spread. There are no USDA approved vaccines for VS. While rare, human cases of VS can occur, usually among those who handle infected animals. VS in humans can cause flu-like symptoms and only rarely includes lesions or blisters.